Jason Burke - Angel Investing Made Better

<p class="MsoNormal">Jason Burke wants a better way for angels to invest in startups. He founded All Stage, the platform for angel investing that powers TBD Angels which he also co-founded.  In this illuminating interview Jason discusses how All Stage helps the angel ecosystem. We also chatted about Moolah Kicks, and Folia Health.</p> <p class="MsoNormal">Here's how All Stage's deal looks like in the All Stage platform:</p> <p class="MsoNormal"><a href="http://bit.ly/allstageInAllstage" rel="noopener" target="_blank"> All Stage deal within the All Stage product</a></p> <p class="MsoNormal">Highlights: </p> <p class="MsoNormal"> ●      Sal Daher Introduces Jason Burke</p> <p class="MsoNormal"> ●      All Stage and the Problem it's Solving</p> <p class="MsoNormal"> ●      "... Because unless you've done sales a lot, it's really hard to deal with rejection, especially for scientific founders..."</p> <p class="MsoNormal"> ●      "... It's an example of some of the connective tissue between Showcase, the founder tool, and Community, the investor tool, to allow for that collaboration to happen..."</p> <p class="MsoNormal"> ●      Moolah Kicks</p> <p class="MsoNormal"> ●      Folia Health</p> <p class="MsoNormal"> ●      Jason's Entrepreneurial Journey</p> <p class="MsoNormal"> ●      "... I built the Tufts cross-country site, which today in 2023 doesn't seem groundbreaking, but at the time having a password on a site and detecting the IP address of who's using it and greeting them, that sort of stuff was absolute magic to do..."</p> <p class="MsoNormal"> ●      "... which came first? Angel investing or starting a company?"</p> <p class="MsoNormal"> ●      "... Was it a personal relationship, the first investment that you made as an angel?"</p> <p class="MsoNormal"> ●      Advice to the Audience</p>

00:41:21

Milena Peregrino, PhD - Reversing Muscle Loss

<p class="p1">Angel Scale Biotech: <a href="https://syndicate.angelinvestboston.com/en-us/the-surge-of-opportunities-in-angel-scale-biotech"> Learn More</a></p> <p class="p1"> </p> <p class="p1">Brazilian startup MirScience Therapeutics is working on reversing muscle loss. I had an illuminating chat with co-founder Milena Peregrino, PhD about the technology and the company’s progress. </p> <p class="p2"> </p> <p class="p2">Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.</p> <p class="p2"> </p> <p class="p1">Highlights:</p> <ul class="ul1"> <li class="li3">Sal Daher Introduces Milena Peregrino</li> <li class="li3">MicroRNAs and What They Do</li> <li class="li3">MirScience Therapeutics</li> <li class="li3">"... Keeping in mind that we're talking about mouse models, it has not gone into human trials yet, but this is very promising..."</li> <li class="li3">"... We are going to need the non-rodent species. For now, we are planning to go with non-human primates, so monkeys..."</li> <li class="li3">How MirScience Was Founded</li> <li class="li3">Milena's Background</li> <li class="li3">"... Most people die from the results from falls. It's not necessarily immediately, it's within six months. If they have a severe fall, old people decline very fast and so this has huge implication for people to age better. The ability to have muscular old people going around instead of frail people who fall over easily..."</li> <li class="li3">Why Milena Chose Biology</li> <li class="li3">Advice to the Audience</li> </ul> <p class="p2"> </p> <p class="p1">Topics: biotech, discovering entrepreneurship, founding story</p>

00:35:46

Agustin Lopez Marquez - AI for Discovery Dining

<p class="MsoNormal">Repeat founder Agustin Lopez Marquez, ex-nference, brings his AI savvy to food delivery with his new startup. Built on CloudKitchens’ infrastructure, Mowgli addresses pain points for diners, sous-chefs and drivers. Loved my chat with this brilliant and practical founder. Sample Mowgli’s homey meals from exotic places at <a href="https://khipi.com/">https://khipi.com/</a>. (delivers only to Boston & Cambridge for now)</p> <p class="MsoNormal"> </p> <p class="MsoNormal">Highlights:</p> <p class="MsoNormal"> </p> <p class="MsoNormal"> ●      Sal Daher Introduces Agustin Lopez Marquez</p> <p class="MsoNormal"> ●      "... my co-founder, who happens to be my wife, Brinda, she was the one that started the company and the first product about a couple of years back..."</p> <p class="MsoNormal"> ●      "... The idea here is that these are meals for explorers, for people who like to venture out, travel. This is not pizza or your usual weekend fare for the kids, and so forth..."</p> <p class="MsoNormal"> ●      "... it's an infrastructure play that has happened in the last three to five years. It's modular kitchens that are just the kitchens that are meant for delivery-only companies..."</p> <p class="MsoNormal"> ●      "... You're going to become like the McDonald's of adventurous eating..."</p> <p class="MsoNormal"> ●      "... we already have more than 10 drivers that consistently, every Tuesday, they choose to work for Khipi as opposed to working for any other food delivery company..."</p> <p class="MsoNormal"> ●      "... I understand you have 400 customers ordering right now. 90 of those are super dedicated and they order every week. They give you 80% of your business..."</p> <p class="MsoNormal" style="margin-left: .5in;">  </p> <p class="MsoNormal">Topics: co-founders, culture, discovering entrepreneurship, robotics/AI</p> <p class="MsoNormal">Title: AI for Discovery Dining</p>

00:38:25

Todd Zion, PhD - More Magical Proteins

<p class="p1">Angel Scale Biotech: <a href="https://syndicate.angelinvestboston.com/en-us/the-surge-of-opportunities-in-angel-scale-biotech"> Learn More</a></p> <p class="p1"> </p> <p class="p1">Repeat founder Todd Zion, PhD is back to update us on exciting developments at his second biotech startup, Akston Bio. We also geeked out a bit on how these magical proteins are concocted in the company’s bioreactors. Fun and instructive chat with a stellar founder.</p> <p class="p2"> </p> <p class="p2">Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.</p> <p class="p2"> </p> <p class="p1">Highlights:</p> <ul class="ul1"> <li class="li3">Sal Daher Introduces Todd Zion</li> <li class="li3">Akston Bio's Founding Story</li> <li class="li3">"... The antigen in this case is the person's own insulin..."</li> <li class="li3">"... you're still taking advantage of that antibody portion, but you've neutered it so that it no longer alerts the immune system, but it retains one property that antibodies all have, which is the ability to recycle and last for very long periods of time in circulation..."</li> <li class="li3">"... We took the veterinary candidates and we partnered those with a company called Dechra Pharmaceuticals, PLC. They're one of the leaders in veterinary pharma development and this is all in the public domain..."</li> <li class="li3">"... We made a pivot at that point saying, 'Well, what if we just go back to the portion of the antibody that interacts with the immune system and make ourselves a vaccine against COVID-19 using the same exact technology?'..."</li> <li class="li3">"... you're going to continue involved in manufacturing, or are you just going to buckle down in the veterinary space and spin off these other technologies to other players?..."</li> <li class="li3">"... if you're not pivoting at least once in your development, you're probably doing something wrong..."</li> <li class="li3">Todd's Funding History</li> <li class="li3">"... what goes on in a bioreactor, which is the heart of what you're doing? Geek out a little bit of bioreactors..."</li> <li class="li3">"... there are these companies that do nothing but transfect CHO cells to produce particular types of protein..."</li> <li class="li3">Energesis</li> </ul> <p class="p4"> </p> <p class="p3">Topics: biotech, COVID, discovering entrepreneurship</p>

00:45:31

Eddie Martucci, PhD - Digital Therapy for ADHD

<p dir="ltr">Angel Scale Biotech: <a href="https://syndicate.angelinvestboston.com/en-us/the-surge-of-opportunities-in-angel-scale-biotech"> Learn More</a></p> <p dir="ltr"> </p> <p dir="ltr">Rather than purloin my kids' Ritalin, I play EndeavorOTC daily to improve my attention and be sharper. Eddie Martucci, PhD is the founder of Akili that developed the app which is backed by real science. In fact, the kid's version is FDA-cleared to treat ADHD in 8-12 year olds. Don't miss this great chat. </p>  </p> Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.</p>  </p> <p dir="ltr">Highlights:</p> <ul> <li dir="ltr"> <p dir="ltr">Sal Daher Introduces Eddie Martucci</p> </li> <li dir="ltr"> <p dir="ltr">The Science Behind EndeavorOTC</p> </li> <li dir="ltr"> <p dir="ltr">"... This is not IQ. This is attention. You can have extremely high IQ or low IQ and have a high attention score and low IQ or vice versa..."</p> </li> <li dir="ltr"> <p dir="ltr">"... people with ADHD, it is not that they don't want to pay attention ... It's that that system of the brain that allows you to filter out what's irrelevant to your goal and focus in on what's relevant, that part of the brain, that interference filter is weakened..."</p> </li> <li dir="ltr"> <p dir="ltr">"... You cannot become addicted to it because can't do it for more than 25 minutes period..."</p> </li> <li dir="ltr"> <p dir="ltr">Eddie's Entrepreneurial Journey</p> </li> <li dir="ltr"> <p dir="ltr">Advice to the Audience</p> </li> </ul>  </p> <p dir="ltr">Topics: discovering entrepreneurship, founding story, product</p>  </p>

00:38:01

Susan Conover - Piction Health Takes Off

<p class="p1">Angel Scale Biotech: <a href="https://syndicate.angelinvestboston.com/en-us/the-surge-of-opportunities-in-angel-scale-biotech">Learn More</a></p> <p class="p1"> </p> <p class="p1">The third time is the charm for Piction Health. Super founder Susan Conover is back to talk about the third iteration of their business model which is showing promise of scaling profitably. Her AI has ingested a million diagnosed images of hair and skin conditions and is now making dermatologists 15X more productive. See for yourself at PictionHealth.com.</p> <p class="p2"> </p> <p class="p2">Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.</p> <p class="p2"> </p> <p class="p1">Highlights:</p> <ul class="ul1"> <li class="li3">Sal Daher Introduces Susan Conover</li> <li class="li3">What Piction Health is Solving</li> <li class="li3">"... We solve the full problem for patients, end-to-end. If they have a rash or a mole they're worried about, or a case like that, they submit a case, we review that case within 24 hours with our board-certified dermatologist, we call in prescriptions..."</li> <li class="li3">A Typical Consultation at Piction Health</li> <li class="li3">"... How did you discover this? How is it that it dawned on you that this is the direction to go in?..."</li> <li class="li3">"... Dermatologists loving working with us is one of our really important metrics that we want to make it really easy for them..."</li> <li class="li3">"... How can our listeners be helpful to Piction Health?"</li> <li class="li3">Thoughts to the Audience</li> </ul> <p class="p2"> </p> <p class="p1">Topics: biotech, discovering entrepreneurship, robotics/AI</p>

00:28:47

Rabeeh Majidi, PhD - AI for Shoulder Injuries

<p class="p1">Angel Scale Biotech: <a href="https://syndicate.angelinvestboston.com/en-us/the-surge-of-opportunities-in-angel-scale-biotech"> Learn More</a></p> <p class="p1"> </p> <p class="p1">Rotator cuff tears are debilitating. What if you could take action to avoid them? Rabeeh Majidi, PhD founded OrthoKinetic Track to do just that through a wearable device and a predictive algorithm. Listen to our chat to learn more. </p> <p class="p2"> </p> <p class="p2">Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.</p> <p class="p2"> </p> <p class="p1">Highlights:</p> <ul class="ul1"> <li class="li3">Sal Daher Introduces Rabeeh Majidi</li> <li class="li3">What OrthoKinetic Track is Solving</li> <li class="li3">"... What I would say is that orthopedic telemedicine lacks comprehensive physical exams..."</li> <li class="li3">"... How is it that your system solves a problem that is of real interest to the providers?..."</li> <li class="li3">"... it's not just about what you know, but also who you know..."</li> <li class="li3">How Rabeeh Became an Entrepreneur</li> <li class="li3">Parting Thoughts to the Audience</li> </ul> <p class="p2"> </p> <p class="p1">Topics: biotech, discovering entrepreneurship, founding story</p>

00:37:09

Richard Vlasimsky - Finding Lung Cancer Early

<p class="p1">Angel Scale Biotech: <a href="https://syndicate.angelinvestboston.com/en-us/the-surge-of-opportunities-in-angel-scale-biotech"> Learn More</a></p> <p class="p1"> </p> <p class="p1">Richard Vlasimsky is using AI to create a low-cost way of vastly expanding our ability to detect lung cancer early. His algorithm for detecting lung nodules in chest x-rays just got FDA clearance. Listen to this remarkable founder who’s done a lot with modest funding.</p> <p class="p2"> </p> <p class="p2">Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.</p> <p class="p2"> </p> <p class="p1">Highlights:</p> <ul class="ul1"> <li class="li3">Sal Daher Introduces Richard Vlasimsky</li> <li class="li3">What IMIDEX is Solving</li> <li class="li3">"... how much your studies cost to get your 510k.."</li> <li class="li3">"... We had multiple radiologists looking at the image, and then we had a final truther that adjudicated these independent reads that the radiologist did..."</li> <li class="li3">"... Payers care about catching it early so that they have better outcomes and the costs are much lower ... The providers, being the medical systems or the physicians, typically hospitals, they care about it because of liability issues and also because they could have the opportunity to treat something and they would get the revenue stream..."</li> <li class="li3">"... It's like a very fine-tooth comb picks up all the nits. The specificity relates to how many of those things that you pick up are actually what you're looking for and not false positives..."</li> <li class="li3">Exit Possibilities</li> <li class="li3">"... his definition of a startup is an enterprise that uses resources that it does not yet command..."</li> <li class="li3">Richard’s Entrepreneurial Journey</li> <li class="li3">"... You had this experience of joining a startup, then creating your own startup which was using machine learning..."</li> <li class="li3">Advice to the Audience</li> </ul> <p class="p2"> </p> <p class="p1">Topics: biotech, discovering entrepreneurship, robotics/AI, founding story</p>

00:41:53

Ben Holmes - Growing New Cartilage

<p class="p1">Angel Scale Biotech: <a href="https://syndicate.angelinvestboston.com/en-us/the-surge-of-opportunities-in-angel-scale-biotech"> Learn More</a></p> <p class="p1"> </p> <p class="p1">Growing new cartilage in your knees is a dream about to become reality. Listen to Ben Holmes, PhD, co-founder of Nanochon, to learn about his promising technology. Shoutout to Richard Meiklejohn of M2D2 for the introduction. </p> <p class="p2"> </p> <p class="p2">Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.</p> <p class="p2"> </p> <p class="p1">Highlights:</p> <ul class="ul1"> <li class="li3">Sal Daher Introduces Ben Holmes</li> <li class="li3">What Problem Nanochon is Solving</li> <li class="li3">"... That's really what we're looking to do, is offer a solution that can be a much easier, much more cost-effective solution for providers, but also something that can really provide much better short and long-term outcomes for patients, and, ultimately, make the knee replacement obsolete..."</li> <li class="li3">The Solution: What it is, and How it Works</li> <li class="li3">"... We're seeing much better repair, and we're doing it with something that's an easy-to-use, off-the-shelf product..."</li> <li class="li3">What is I-Corps?</li> <li class="li3">Future Funding Plans</li> <li class="li3">Names and Numbers</li> <li class="li3">Ben's Entrepreneurial Journey</li> <li class="li3">Advice to the Audience</li> </ul> <p class="p4"> </p> <p class="p1">Topics: biotech, discovering entrepreneurship, founding story</p>

00:41:37

Drew Madson - Young Readers Win Big

<p class="p1">Angel Scale Biotech: <a href="https://syndicate.angelinvestboston.com/en-us/the-surge-of-opportunities-in-angel-scale-biotech"> Learn More</a></p> <p class="p1"> </p> <p class="p1">During COVID, Readlee, Drew Madson’s startup, offered teachers a highly effective way to measure and remedy reading deficits among online learners. This led to the company being acquired by Paper, the tutoring platform. An inspiring interview.</p> <p class="p2"> </p> <p class="p2">Sponsored by Purdue University entrepreneurship and Peter Fasse, patent attorney at Fish and Richardson.</p> <p class="p2"> </p> <p class="p1">Highlights:</p> <ul class="ul1"> <li class="li3">Sal Daher Introduces Drew Madson</li> <li class="li3">What Readlee is Solving</li> <li class="li3">Behind the Scenes of Readlee</li> <li class="li3">How Readlee Came to Be</li> <li class="li3">"... COVID just highlighted this need that already existed..."</li> <li class="li3">"...I highly recommend checking out The Opportunity Atlas. If listeners haven't looked at this, it's an amazing analysis of how certain interventions can actually improve people's ability to make more money over the course of their lives and have more opportunity and flourishing..."</li> <li class="li3">"... What are large language models going to do to this space?..."</li> <li class="li3">How Drew Developed an Interest in Education</li> <li class="li3">Parting Thoughts</li> </ul> <p class="p1"> </p> <p class="p1">Topics: discovering entrepreneurship, founding story, product</p>

00:40:00